Bipartite Community Structure of eQTLs
Fig 1
Overview of the CONDOR algorithm.
All possible SNP-gene pairs from an appropriate data set are considered in an eQTL analysis. Both cis- and trans-acting eQTLs (FDR < 0.1) are used to construct a bipartite network linking SNPs and genes. The resulting network structure is then analyzed, first globally to understand its overall structure and to identify network “hubs.” Then the community structure of the bipartite network is determined, each community is subject to functional enrichment analysis, and a core score is calculated to identify those SNPs most likely to disrupt individual communities.