Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks
Fig 3
Set efficiency and evolutionary rate for AML 2.3.
The cumulative set efficiency (SE) of all genes below a given evolutionary rate (ER) rank (lowest to highest ER, i.e. “coldest” to “hottest”). The SE of the 500 coldest genes is significantly higher than the control, and including hotter genes monotonically decreases the SE. This indicates that the coldest genes exchange information efficiently, while the hottest genes are more dispersed and thus communicate less efficiently.