The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics
Fig 4
Predicted values for a) adherens junctions (AJ) and b) adhesivity (σ) when numerically solving RCN model.
The four conditions simulated the experimental conditions: reference condition corresponds to physiological rate of β-catenin/TCF complex formation (i.e. equilibrium constant K11, S1 Table); dysregulated condition corresponds to ICG-001 treatment, modeled as a disruption in β-catenin/TCF complex formation (i.e. rate constant changed to 2×K11). Wnt “OFF” state is modeled with a total Wnt3a concentration WNT0 = 1 nM, and Wnt “ON” with WNT0 = 28.062 nM.