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Inverse Stochastic Resonance in Cerebellar Purkinje Cells

Fig 4

Hysteresis and ISR of the aEIF model.

A Voltage response of the aEIF model to Ornstein-Uhlenbeck current noise injection with increasing amplitude. B. Mean firing rate of the aEIF model in response to current noise stimulation with amplitude σ and mean I (color code). C. Hysteresis of the aEIF model. Top, voltage response to ascending (red) and descending (blue) ramp of current. Bottom, instantaneous firing rate vs. instantaneous injected current. Color code is the same as in B. D. Parameter space of the rescaled aEIF model, white region: type I excitability, gray region: type II excitability. The 7 fitted cells are in the type II region. E, F. Dependence of the hysteresis size ΔI on the parameters T τw/τm (E) and A = a/gL (F). G. Membrane potential distribution in the aEIF model during spiking and silent states.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1005000.g004