Modelling of Yeast Mating Reveals Robustness Strategies for Cell-Cell Interactions
Fig 2
Effect of external and internal noise on yeast mating simulations.
(A) Varying a-factor diffusion rates under no-noise simulation conditions. The diffusion constant for a-factor Da was set to 0.1, 1, 10, and 100 μm2/s; the diffusion constant for α-factor was Dα = 100 μm2/s. The cell centers were separated by 4 μm at the start. In all cases the cells were able to grow toward each other successfully. (B) External and internal noise disrupt mating. External (κ1) and internal (κ2) noises were added to the simulations using a range of values (0, 5, 10, 50 for κ1; 0, 3, 5 for κ2). 10 simulations were run for each combination, and an example simulation is shown for each specified pair of values (κ1, κ2). (C) Varying a-factor diffusion rates in the presence of noise. Simulations performed as in (A) except in the presence of noise (κ1 = 5, κ2 = 3). All simulations produced mating except Da = 0.1.