Intercellular Variability in Protein Levels from Stochastic Expression and Noisy Cell Cycle Processes
Fig 5
Model illustrating stochastic expression together with random gene-duplication and cell-division events.
At the start of cell cycle, protein production occurs in stochastic bursts with rate kx. Genome duplication occurs at a random point T1 within the cell cycle and increases the burst arrival rate to fkx (f > 1). Cell division occurs after time T2 from genome duplication, at which point the burst arrival rate reverts back to kx and proteins are randomly partitioned between cells based on Eq (4).