PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions
Fig 3
The use of category-optimal thresholds improves the predictive performance of individual tools by increasing their ability to capture differences in the distribution of prediction scores for the different categories of variants.
(A) Distribution of scores for deleterious and neutral variants provided by each evaluated tool for individual categories of variants from the training subsets of the Mendelian diseases dataset. The locations of the general and category-optimal thresholds used to obtain predictions are shown for each tool. (B) Normalized accuracies achieved by individual tools when using category-optimal (blue bars) and general (red bars) thresholds, evaluated using testing subsets of the Mendelian diseases dataset.