Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches
Fig 6
Free energy landscapes of additional switch sequences in the GA/GB system.
Plotted in the same style as that in Fig 5. (a) GB98-T25I (PDB:2LHG). (b) GB98-T25I,L20A (PDB:2LHE). PDB structures in (a) and (b) are depicted by the ribbon diagrams. (c) Predicted switch sequence “S1” prefers GB whereas (d) sequence “S2” prefers GA [66]. The arrows mark the global minimum in each of the energy landscapes.