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Structural Determinants of Misfolding in Multidomain Proteins

Fig 9

Ising-like model.

a) Monte Carlo simulation trajectory segment when E_p = 4.0 kcal/mol. The free energy profile of vs Q_res changes when the difference of the stability between the WT and the circular permutant become larger and larger, in which cases the E_p are b) 0.0, c) 4.0 and d) 6.0 respectively. All the free energy plots are at the temperature T = 525 K.

doi: https://doi.org/10.1371/journal.pcbi.1004933.g009