Structural Determinants of Misfolding in Multidomain Proteins
Fig 7
Transition paths for the formation of the first (folded or misfolded) domain in tandem SH3 dimers.
Folding (a) and misfolding (c) kinetics are projected along the reaction coordinate Qin, where two different kinds of Qin are chosen depends on K, which is for the native fold and the circular permutated misfold when K = 0 and 18, respectively. Transition-path segments are defined as being between QK = 0.1 and QK = 0.9. In the right panels, the same trajectories are projected onto the QK = 0 and QK = 18 (panel (b) for trajectories in (a) and (d) for those in (c).