Structural Determinants of Misfolding in Multidomain Proteins
Fig 4
Comparison of domain-swapped misfolds with experimental structures.
Selected misfolded dimeric tandems obtained from the simulations (right column) are compared with corresponding experimental structures (solved by crystallography or NMR) of domain-swapped dimers involving two separate protein chains (left column). The proteins are, from top to bottom (a),(b): SH3, (c),(d): SH2, (e),(f): TNfn3 and (g),(h): PDZ domains The PDB accession codes are 1I07, 1FYR, 2RBL and 2OSG respectively.