Progression of Diabetic Capillary Occlusion: A Model
Fig 9
(CASE1) oxygen tension pattern following initial capillary occlusion.
(A) Oxygen tension map shows a localized hypoxic region near the occluded capillary in week 0. (B) Hypoxic area of cells broadened to enclose a second occlusion site in week 72, but it’s still restricted and confined spatially to the arteriole-venule sector. (C) Local insult by hypoxia propagated to break the terminal capillary near the venule and extended to the neighboring AV sector in week 124. (D) Large area of hypoxia was observed in week 152. Color reflects magnitude of oxygen tension. The redder the color the higher the oxygen tension is. The unit for oxygen tension is mmHg. “FAZ” in the figure refers to foveal avascular zone, “A” in red refers to arteriole, and “V” refers to venule.