Progression of Diabetic Capillary Occlusion: A Model
Fig 3
Schematic of oxygen and VEGF fluxes.
Colored blocks represent model objects: Capillary block (CAP in red), Fluid portion (FP in cyan), Mueller cell (MC in green) and Other retinal cells (OT in brown). Markers in the form arrows, triangles and squares are used to represent modeled fluxes. On the left are the oxygen fluxes including advection, diffusion and metabolism. Oxygen advection is modeled for object CB. Oxygen diffusion is modeled for object pairs among CAP, MC, OT and FP. Oxygen metabolism is modeled only for objects MC and OT. On the right are the VEGF fluxes including synthesis, diffusion and decay. VEGF synthesis is modeled for object MC again as the model’s only VEGF source. VEGF diffusion is modeled for object pairs among CAP, MC, OT and FP. VEGF decay is modeled for objects CAP, MC, OT and FP. The arrangement of model objects do not necessarily reflect detailed configurations constructed in the simulations.