Progression of Diabetic Capillary Occlusion: A Model
Fig 2
Model abstraction and construction of human perifoveal capillary network from an Adaptive Optics Scanning Laser Ophthalmology (AOSLO) image.
On the right, AOSLO image shows juxtafoveal capillaries adjacent to the foveal avascular zone (FAZ). This is a normal capillary map in a patient without diabetes. On the left, a model schematic shows the reconstruction of the capillary network framed in the AOSLO image with cells filling in empty space between vessels uniformly. Capillary network has arteriole (A) and venule (V) termini marked. Boundary blood pressures are assigned for A and V termini. Boundary oxygen tensions are assigned for A terminus and for FAZ whereas venous oxygen tension is model dependent. Model objects in red, green, brown are capillary blocks (CAP), Mueller cells (MC) and other retinal cells (OT) respectively. Yellow pixels surrounding objects are object borders, which are muted in other figures of the manuscript. Note that this example shows a macular capillary network from a different subject than that shown in CASE 1. Diameter of the FAZ in this ASOLO image is approximately 500 microns. The scale bar is 100 microns.