A Detailed Data-Driven Network Model of Prefrontal Cortex Reproduces Key Features of In Vivo Activity
Fig 5
Propagation of transient input.
(A) Raster plot of the spike times in the network in response to an external input (gray line) to 10% of the L2/3 pyramidal cells. The input currents are Iex = 250 pA, Iinh = 200 pA. (B) Same as Panel A, but with a stronger (higher rate) external stimulus (see text for details). (C) Same as Panel A, but with neuron parameter variability reduced by 80% (standard deviation set to 20% of its original value). (D) Number of spikes in response to the input as a function of neuron parameter variability. Each data point is the mean ± SEM over a number of repetitions.