Biophysical Network Modelling of the dLGN Circuit: Different Effects of Triadic and Axonal Inhibition on Visual Responses of Relay Cells
Fig 4
Synaptic integration properties of interneuron (IN) model.
(A) Ball-and-sticks IN model consisting of a point-like soma (black square) with five dendritic sticks protruding out from it. Distal (triadic; blue dots) and proximal (red dots) synapse locations are illustrated. Panels B–E shows spatiotemporal spread of IN membrane potential along two (of five) dendritic sticks following activation by single RC spiking on inputs distal (triadic) and/or proximal synapses. Each colored line represents a snapshot of the membrane potential taken each half millisecond from 0 to 20 milliseconds with the GC spike(s) arriving at tsyn = 1 ms. The synapse position(s) are denoted by vertical, red or blue dashed lines, while the black dashed line marks the location of the soma compartment. The small inset axes show the membrane potential in the soma (Vi(0, t)) and in the distal dendrite (Vi(−450 μm, t)), respectively, as a function of time. (B) GC spike onto distal synapse on lower left dendritic stick. (C) GC spike onto proximal synapse on lower left dendritic stick. (D) GC spike arriving simultaneously on distal and proximal synapses on lower left dendritic stick. (E) GC spikes arriving simultaneously at all five proximal synapses, including those on the two depicted dendritic sticks.