EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT
Fig 9
The pipeline used to determine the effects of active AKT signaling on the EMT metabolic network.
The metabolic genes predicted to be altered in D492 and D492M dependent on the AKT signaling network, were used to constrain the EMT metabolic network generated from Recon2, in order to identify downstream metabolic pathways that are affected by AKT activation.