EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT
Fig 4
Flux differences between epithelial network (EGFR_E) and mesenchymal network (EGFR_M).
A) Probability density estimates for the flux values in selected reactions as obtained by random sampling. The blue curve represents the flux distribution of EGFR_E and the red curve that of EGFR_M. Vertical axis denote probability and flux values are represented on the horizontal axis. AU: arbitrary units B) Relative mean flux for each reaction in EGFR_E and EGFR_M through the AKT, RAS and DAG/IP3 and CaM pathways. Higher flux within reactions in AKT and RAS/MAPK pathways are observed in the EGFR_E network compared to EGFR_M while CaM and DAG/IP3 have higher flux in EGFR_M. Negative values denote higher flux in EGFR_E and positive values denotes higher flux in EGFR_M. Numerical values of these fluxes are given in supplementary file (S1 File).