Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations
Fig 7
Hysteresis cycles of a single myofibril.
A A single myofibril consisting of 7 sarcomeres was stretched to an averaged sarcomere length of 3.7μm and subsequently cycled by approximately ± 2.5μm. The small insert shows the corresponding average sarcomere length (red line) ± standard error (black lines). The peak forces declined from the first to the second last peak. B The average force of Monte Carlo simulations based on 200 titin strands and a simplified half sarcomere length behavior (small insert) show a decline of peak forces based on the folding / unfolding behavior of Ig domains.