Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations
Fig 6
A Monte Carlo simulations and B exact solution of hysteresis loops based on one Ig cluster of the following setup: a half sarcomere was subject to two subsequent stretch-shortening cycles. After a resting period of 30s another stretch-shortening cycle was performed. We observed that while hysteresis was significantly reduced in the second cycle it fully recovered in the third cycle due to refolding of Ig domains in the resting period [5]. The effect of repeated stretch-shortening cycles on the unloading energy remains negligible.