Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations
Fig 3
Force-elongation behavior of a single titin strand with corresponding Monte Carlo simulations and force-elongation relation of a myofibril.
A When a single titin molecule is stretched it shows a typical saw-tooth pattern due to the unfolding of Ig domains [5, 9, 36, 38]. Three exemplar Monte Carlo simulations simulate that behavior. B Force-elongation curves of two myofibrils consisting of 7 and 8 sarcomeres respectivley. The shaded region indicates the standard error of the mean sarcomere length. Since over 1000 titin molecules are arranged in parallel in a single half sarcomere the saw tooth pattern observed in single molecule experiments is averaged out.