HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data
Fig 4
Plot of the simulated concentrations over time for extracellular fructose (eFru), fructose 1-phosphate (Fru1P), cytosolic phosphate (cPi) and cytosolic ATP (cATP).
Specifically, the simulated concentrations in hepatocytes incubated with 20 mM glucose and 3 mM fructose (conditions A1 and A2, described in the main text) or 20 mM glucose and 20 mM fructose (condition B, described in the main text) are shown. The red plot indicates the values predicted with the best fit parameter set and the grey area indicates the estimated range of variations taking parameter sets within the 95% confidence intervals derived from the identifiability analysis.