HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data
Fig 3
Bar graphs representing the experimentally determined metabolite productions (3.A) and isotopologue fractions (3.B) in experimental conditions.
Measurements were taken after incubating hepatocytes for 2 hours with 20 mM glucose 50% enriched in [1,2-13C2]-glucose and 3 mM fructose (condition A1), 20 mM glucose and 3 mM fructose 50% enriched in [U-13C6]-fructose (condition A2) and 20 mM glucose 50% enriched in [1,2-13C2]-glucose and 20 mM fructose (condition B). The red dot indicates the value fractions simulated by HepatoDyn using the best fit parameter set. Results of the isotopologue fractions are reported as m0, m1, m2, etc. where m0, m1, m2… indicate the number of 13C atoms in the isotopologue fractions of a given metabolite.