HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data
Fig 2
Schematic representation of the metabolic network used in the model.
In this representation, reactions associated with the glycolytic and gluconeogenic pathways are coloured in blue, reactions associated with glycogen metabolism are coloured in purple, reactions associated with the pentose phosphate pathway are coloured in pink, reactions associated with the Krebs cycle are coloured in orange, reactions associated with fatty acid metabolism are coloured in red and other reactions associated with redox and energy metabolism are coloured in green. Specifically, the reactions id of each reaction represented are 1:glctr, 2: gka, 3 g6pasea, 4: gkb, 5: g6paseb, 6: gpia, 7: gpib, 8: pfkla1, 9: fbasea1, 10: pfklb1, 11: fbaseb1, 12: pfkla2, 13: fbasea2, 14: pfklb2, 15: fbaseb2, 16: aldo1, 17: aldo2, 18: aldo3, 19: tim, 20: trik, 21: fruhk, 22: frutr, 23: gapdh, 24: pgk, 25: pgm, 26: eno, 27: pepck, 28: pk, 29: ldh, 30: lactr, 31: pyrtr, 32: mpyrtr, 33: pc, 34: dic, 35: pglm, 36: ugt, 37: gs, 38: gp, 39: g6pdh, 40: pgndh, 41: rpi, 42: rul5pepi, 43: tk1, 44: tk2, 45: tk3, 46: ta, 47: pdh, 48: cs, 49: aco, 50: idh, 51: kdh, 52: scs, 53: sdh, 54: fh, 55: mmdh, 56: malic, 57: citmtr, 58: citly, 59: acoacar, 60: fasyn, 61: box, 62: aatc, 63: aspglumtrans, 64: aatm, 65: malkgmtrans, 66: cmdh, 67: transa, 68: glutr, 69: glyc3pcdh, 70: glyc3pmdh, 71: nadhdh, 72: coqhoxi, 73: atpase, 74: pimtr, 75: pitr, 76: ppase, 77: atpmtrans, 78: cndk1, 79: cndk2, 80: mndk and 81 adk. Invisible reactions are not shown for clarity. The full lists of metabolites and reactions can be found on S1 and S2 Tables respectively.