The Role of Genome Accessibility in Transcription Factor Binding in Bacteria
Fig 5
Genome accessibility is affected by GC content and distance to oriC.
(A) Accessibility is negatively correlated with local genomic GC content. The correlation between accessibility values and region GC content after controlling for values of motif affinity is -0.30 (p < 10−179; function pcor and pcor.test, R package ggm). (B) Accessibility does not appear to correlate with genome position. (C) Accessibility is negatively correlated with distance to oriC. (D) A schematic of genome replication that could explain the correlation between accessibility and distance to origin of replication.