Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory
Fig 9
(9:1)-mixed population of S toggles.
Panels (A) and (B) correspond to large and small subpopulations of a (9:1)-population of S toggles. All notations and color-coding schemes are as in Fig 7. Red filled circles correspond to the same LP-bifurcation point. In panel (A), projections of stable and unstable solution branches overlap. Because TetR is totally suppressed in the large (90%) subpopulation, the levels of TetR are not shown. Contrarily to panel (A), both TetR and LacI levels are plotted in panel (B) since LacI is only moderately suppressed in the small (10%) R-subpopulation.