Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes
Fig 7
Examples of newly identified and better defined Cache domains in diverse signal transduction proteins from bacteria, archaea and eukaryotes.
Domain architectures for representative sequences from model organisms are shown along with their UniProt accession numbers. Newly defined Cache domains are shown in red. Cache boundaries defined by the previous Pfam models are shown in pink (Cache) and green (MCP_N). HAMP domains are shown as grey circles, PAS domains as cyan circles, and HisKA domains as white circles. Other Pfam domains are abbreviated as follows: MCP, MCPsignal; GGDEF, GGDEF; GC, guanylate cyclase; HK, the histidine kinase HATPase_c domian; RR, response regulator; VWA, a combination of VWA_N and VWA domains; VGCC, VGCC_alpha2.