APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone
Fig 4
Subcommunity structure of the network based on Fig 3B.
The color code corresponds to the pie chart diagram (cf. Fig 1E). The size of the rings corresponds to the respective number of proteins. Communities (1–7) were subdivided into the following functional clusters (e.g. 1.1–1.12): 1.1 Calcium Signaling, 1.2 Presynaptic Membrane, 1.3 Exocytosis, 1.4 Cytoskeleton Organization, 1.5 Membrane Assembly, 1.6 G-Protein Signaling, 1.7 Organelle Transport, 1.8 Actin Organization, 1.9 Synapse Assembly, 1.10 Membrane Regulation, 1.11 Inhibitory Regulation, 1.12 Vesicle Priming, 2.1 Membrane Trafficking, 2.2 Vesicle Budding, 2.3 Endocytosis, 2.4 Proton Transport, 2.5 Phospholipid Metabolism, 2.6 Vesicle Organization, 2.7 Membrane Organization, 3.1 Electron Transport Chain, 3.2 Energy Metabolism, 3.3 Stress Defense, 4.1 Cellular Respiration, 4.2 Glycolysis, 4.3 Guanine Metabolism, 4.4 Glycerol Metabolism, 4.5 Mitochondrial Metabolism, 4.6 Mitochondrial Assembly, 5.1 Fatty Acid Catabolism, 5.2 Neurotransmitter Metabolism, 5.3 Amino Acid Catabolism, 5.4 Metabolism, 5.5 Fatty Acid Metabolism, 5.6 Mitochondrial Targeting, 6.1 Mitochondrial Protein Trafficking, 6.2 Heatshock Response, 6.3 Neuronal Regulation, 6.4 Protein Folding, 7 Functional Dynamics.