Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells
Fig 1
(A) Diagrammatic representation of all potential entities considered in the model repertoire according to mRNA expression data [13]. (B) Diagrammatic representation of the potential entities based on the most parsimonious solution (ℓ1-norm; see text for further details). SR: sarcoplasmic reticulum; CaCC: calcium-activated chloride channel; CaT: T-type calcium channel; CaL: L-type calcium channel; hERG: human ether-à-go-go-related gene potassium channel; Kvx.x: potassium channel; SK-x: “small unitary current” potassium channels; BK-x: “big unitary current” potassium channels; NCX: sodium-calcium exchanger; PMCA: plasma-membrane calcium exchanger; pNaK: sodium-potassium exchanger; bgK: background potassium current; bgCl: background chloride current.