Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
Fig 9
Magnitude of the rigid body moves of the helices necessary to map one structure to another.
All TMs 1–7 from all available structure pairs were compared and each symbol denotes which TM is the data point from. The coordinate system is defined in the text. The maximal observed deviation is approximately proportional to the sequence dissimilarity of the two compared TMs, and it follows the same trend within class A (blue symbols) and across the GPCR superfamily (green symbols). The red symbols, which correspond to the active-inactive structure pairs, show rigid body moves caused by receptor activation. S10 Fig has an analogous plot of residual RMSD vs. similarity for each helix after the best rigid body transformation. RMSD shows a similar trend as the plots in this figure.