Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
Fig 5
TM 3 sequence alignment for the 25 crystal structures.
Other TMs are shown in Fig 6. The sequences are taken from the selected PDB files. The TM helix residues are colored in the Zappos scheme, which captures the chemical nature of each residue (e.g. helix breakers, proline and glycine, are shown in purple). The loop residues are shown in grey. The BW n.50 residue (numbering displayed below the sequences) is the most conserved within the class A. The consensus sequence is most similar to class A, because most sequences are from this class. The largest differences are for the last 5 sequences, which belong to the classes B, C, and F. The figure was prepared using Jalview.