Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
Fig 4
Testing the robustness of the alignment of the Taste2 receptors with the other groups.
The table shows similarity between TMs averaged over all pairs of sequences formed from the two groups (red denotes high similarity, blue low similarity). For most TMs the optimal choices agree with the optimal alignment to Aα (full table in S6 Fig) only TM6 shows a second possible alignment at offset +4. The same table but using the GPCRtm substitution matrix instead of BLOSUM62 is in S8 Fig. Again, both matrices result in the same alignment.