Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications
Fig 1
TM domains of the available crystal structures.
Top: Two views of the 24 inactive crystal structures from classes A, B, C, and F (aligned to β2) show the general GPCR fold of the transmembrane (TM) bundle. Class A in green, class B in blue (CRF1, GLR), class C in orange (MGLU1, MGLU5), class F in magenta (SMO). Bottom: Same views for only the 19 inactive class A structures showing the highly conserved class A TM fold. A detailed view of the conserved hydrogen bonding networks is shown in S1 Fig.