Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
Fig 7
Deterministic simulation trajectories of the intact system in response to 2-Gy and 10-Gy irradiation.
(A) 2-Gy irradiation is insufficient to trigger apoptosis and after several oscillations system recovers to the survival steady state. (B) 10-Gy irradiation is sufficient to trigger apoptosis: after two oscillations p53KILLER stabilizes at a high level triggering apoptosis.