Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
Fig 1
Simplified scheme of the model.
Arrow-headed dashed lines indicate positive transcriptional regulation, arrow-headed solid lines—protein transformation, circle-headed solid lines—positive influence or activation, hammer-headed solid lines—inhibitory regulation. Pro-survival and cell cycle-promoting proteins are represented with blue boxes, pro-apoptotic proteins with yellow boxes, proteins involved in cell cycle arrest with green boxes. Details of the cell cycle arrest module and the apoptotic module are shown in Figs 2 and 3 respectively.