Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin
Fig 4
Prediction of depalmitoylation kinetics.
A: WT calnexin was labelled with 3H-palmitate in silico either for two hrs or to reach the steady state distribution of palmitoylation species. B: The kinetics of palmitate loss starting from the two distributions in A were determined. The solid lines represent the means of the simulations of 382 models and the shaded areas are defined by the first and the third quartile of the simulations of 382 models (details of the in silico labelling experiment can be found in the Expanded View). C: The rate constants for depalmitoylation from c1CAL, c2CAL and c1c2CAL where determined. Error bars correspond to first and third quartile of the simulations of 382 models.