metagene Profiles Analyses Reveal Regulatory Element’s Factor-Specific Recruitment Patterns
Fig 3
Metagene profiles in enhancer and promoter regions.
(A) POLR2A, the largest subunit of Pol II. (B) TAF1, a general transcription factor. (C) ELF1, a transcription factor. The x-axis is centered on enhancers and promoters ±1000bp. The y-axis represents the mean occupancy normalized in reads per million (RPM). Each line represents the mean occupancy of the factor replicates. Groups of transcriptional activity of enhancers or promoters are identified by different colors (red = no CAGE signal; green = low CAGE signal; blue = moderate CAGE signal; purple = high CAGE signal). The ribbons represent the 95% confidence interval of the mean calculated using 1000 bootstraps.