Evolutionary Genomics Suggests That CheV Is an Additional Adaptor for Accommodating Specific Chemoreceptors within the Chemotaxis Signaling Complex
Fig 2
Analysis of patterns in sequence conservation suggests interaction between CheVRR domain and CheA-P1.
A) Comparison between sequence logos of CheAP1 from genomes with and without CheV. The CheAP1 active site His48 (black dot) and the only different position between the two sets Gly55 (red dot) are marked. B) Comparison between sequence logos of CheY and the CheVRR domain. Positions that are conserved in both sets are marked (blue dots for solvent exposed positions (10 25 57 65 68 72 82 83 107 116) and blue stars for buried positions (13 18 60 61 63 64 94 103 106 109 111)). C) Cartoon representation of the CheY (white) and CheAP1 (blue) [35]. Solvent exposed positions conserved in CheY and CheVRR datasets localize to the protein interface region (blue spheres). The single position that is different between the sets of CheAP1 with and without CheV, Gly55 (red sphere), lays in the C-terminal part of the second α-helix involved in the interaction protein region that also contains the active site His48 (white CPK representation).