A Network Model to Describe the Terminal Differentiation of B Cells
Fig 5
Nodes represent the fixed point attractors, and the edges correspond to all the possible single-node perturbations able to move the system from one attractor to another. For the continuous model, perturbations are simulated by temporarily change the value of a single node to 0, 1 or 0.5, represented by the symbols “−”, “+” and “int”, respectively. For example, IL-2+ means that a temporal activation of IL-2 is able to cause the system to move from the Naive attractor to the GC attractor. Biologically relevant differentiation routes are represented as blue arrows.