Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces
Fig 3
Compartment size control can emerge from passive mechanical forces.
(A) Snapshots of wt, en>dap and en>CycE simulations, each following the final round of division. Parameter values are listed in Table 1. (B) Comparison of simulated P compartment areas and cell numbers with observed values [14]. Mean values from 100 simulations are shown and error bars are standard deviations. (C) Variation of P compartment area (upper row) and cell number (middle row), and of the number of accumulated cell deaths in the en>CycE perturbation over 100 simulations in the front and back halves of the P compartment (lower row), as each mechanical parameter is varied individually, holding all other parameters at their values listed in Table 1. Shaded areas in (B) and (C) mark the ranges of experimentally observed values and are added for reference (see main text for details).