Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications
Fig 7
Synchronous cell division changes the sense of coherent rotation.
(a) Cells are allowed to undergo division, where each mother cell on attaining a mature cell cycle number will divide and become two daughter cells with equal and opposite polarization (as indicated by black arrows inside the daughter cells). Two cases are analysed where cells are allowed to divide either synchronously or asynchronously. For both cases, initially starting with 40 number of cells, division is continued till number of cells become 80. (b) Even though incapable of change the direction of overall rotation, asynchronized cell division causes local perturbations in the pattern of rotation, which shortly dies down and system continues the steady rotational mode, indicated by the same sign of mean vorticity before and after cell division. (c) In the case of synchronous division of cells, the large perturbations introduced into the system in a short time is capable of inducing the change in the direction of rotation indicated by the opposite signs of mean vorticity before and after the division. Even though the reversal in the direction of rotation after synchronous division has not happened in all the cases analysed, we observed a preferential bias in the change in direction tendency.