Coherent Motion of Monolayer Sheets under Confinement and Its Pathological Implications
Fig 6
Coherent rotation of cells confined in annular geometry.
As observed for circular substrates, cells confined inside annular geometries also exhibit coherent rotation. Simulations done on an annular shaped geometry with outer radius, R and thickness, t show that mean vorticity of system decreases with increase in number density as in the case of a circle. Furthermore, simulations done with two sets of cell numbers (N = 100, represented by green curve and N = 140, represented by blue curve) show that at lower densities, system behaves like an elastic solid, roughly matching their values with analytical results (red points). For higher number of cells, cell behavior is more like an elastic solid for thicker sections. As the thickness of annulus reduced, cell state transitioned from an elastic solid to viscous fluid. The red and magenta curves showing the analytical values of elastic solid and viscous fluid respectively, are derived as explained in main text.