A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression
Fig 4
AMPAR trafficking under basal conditions and during LTD induction.
(Total AMPAR plasma membrane population includes both phosphorylated, at either GluA2-Y876 or GluA2-S880, and unphosphorylated AMPARs.) (A) Effect of PKC and PTPMEG on AMPAR plasma membrane population when exocytosis is blocked. (B) Effect of PTPMEG on LTD induction in the complete model. (C) AMPAR flux across the plasma membrane under basal and LTD induction conditions.