A Computational Model for the AMPA Receptor Phosphorylation Master Switch Regulating Cerebellar Long-Term Depression
Fig 3
Interconversion of the AMPAR phosphorylation states in the model.
(AMPApY = GluA2-Y876-phosphorylated AMPA receptor; AMPApS = GluA2-S880-phosphorylated AMPAR). (A) Influence of AMPAR phosphorylation state on GRIP and PICK1 interactions and trafficking during basal and LTD induction conditions. (B) Interactions between AMPAR and GRIP/PICK1, showing the formation of a tripartite complex.