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Model-Based Evaluation of Spontaneous Tumor Regression in Pilocytic Astrocytoma

Fig 4

Parameter estimation from epidemiological data and derivation of the PA-regression-function.

A. In order to estimate the clinically observed fraction of PA-I, we utilize data from the literature. B. The estimated fraction of PA-I cases is interpreted as absorption probability in state N in our model. Eq (3) allows to estimate the corresponding risk coefficient . C. Substituting the estimated risk coefficient in Eq (5) determines the PA-regression-function β_0.152(ρ) which is plotted in purple. Furthermore, the blue plots indicate the corresponding regression functions for values of γ which are obtained within the standard deviation of .

doi: https://doi.org/10.1371/journal.pcbi.1004662.g004