Structural and Energetic Characterization of the Ankyrin Repeat Protein Family
Fig 6
Local frustration and sequence conservation.
A) Relation between information content per characteristic position in the ankyrin repeat derived from the conservation of the sequence and the conservation of the frustration state. There exists a positive correlation between the two variables with significant p-values (<0.05) for the Internal and C-terminal repeats. The correlation is not significant in the case of N-terminal repeats. B) Configurational frustration index plotted over representative structures of the ANKs family (the consensus protein 4ANK, PdbID: 1n0r,A; Ankyrin1, PdbID: 1n11,A; LegA1 protein from Legionella pneumophila, PdbID: 2aja,A and the P19INK4D CDK4/6 inhibitor, PdbID: 1bd8,A). The green lines correspond to interactions that are minimally frustrated, red lines correspond to highly frustrated interactions.