MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells
Fig 4
Bifurcation diagrams of the DNA double-strand-break triggered steady-state p53 response versus the association rates between the three microRNAs and their five target mRNAs (kon1, kon2, kon3, kon4, kon5) embedded in the positive feedback loops, under the wild-type (black), miR-192 repressed (purple), miR-34a repressed (green), and miR-29a repressed (blue) conditions.
Paired dots represent the bounds of p53 oscillation amplitude and the solid line represents stationary steady state. The red vertical line indicates the nominal parameter value. The inhibition of miR-192 leads to shrunk oscillating region or entirely non-oscillating region over varying parameter ranges. The inhibition of miR-34a and miR-29a only mildly affects the system behavior compared to the wild-type condition.