The Role of Symmetric Stem Cell Divisions in Tissue Homeostasis
Fig 10
Modeling micro-injuries by introducing a certain percent (1%, or 10%, or 20%) decrease in the number of differentiated cells in 0.01% of temporal updates (randomly chosen).
In (a,b) the numbers of SCs and differentiated cells is plotted as functions of time, for a typical run. In (a), most divisions are asymmetric (S = 0.1), and in (b), all divisions are symmetric (S = 1). (c,d) The variance and the relative standard deviation of the number of differentiated cells as a function of the percentage of symmetric divisions. The percent decrease of the number of differentiated cells is marked above each line. Eq (6) with ϵ = 0.002 was used.