Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer
Fig 2
Proposed model scheme of the miR control of HIF-VEGF pathway.
HIF-1α is stabilized in hypoxia and the HIF-1 dimer complex transcriptionally induces let-7 production. Mature let-7 represses AGO1 and leads to a global desuppression of VEGF. Model components in the colored backgrounds correspond to the four modules: blue/O2 sensing, pink/VEGF repression by miR-15a, orange/HIF-dependent transcription, green/let-7 biogenesis and targeting. Species whose names end with an N subscript are located inside the nucleus; reactions that point to red signs indicate degradation. The symbols v# refer to the 57 chemical reactions listed in S1 Table.