Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer
Fig 1
Translational repression of VEGF in normoxia and let-7 mediated VEGF desuppression in hypoxia in ECs.
(A) VEGF mRNA were targeted by miRISC and inaccessible for translation in normoxia. (B) HIF-1 proteins that were stabilized in hypoxia induced let-7 biogenesis, which led to the downregulation of AGO1 mRNA, protein and miRISC formation. VEGF mRNA were desuppressed and ready for translation because of reduced miRISC activities.